TY  -  
T1  - Real-time monitoring of human blood-brain barrier disruption 
SN  -  /  
UR  - http://hdl.handle.net/10138/182237 
T3  -  
A1  - Kiviniemi, Vesa; Korhonen, Vesa; Kortelainen, Jukka; Rytky, Seppo; Keinanen, Tuija; Tuovinen, Timo; Isokangas, Matti; Sonkajarvi, Eila; Siniluoto, Topi; Nikkinen, Juha; Alahuhta, Seppo; Tervonen, Osmo; Turpeenniemi-Hujanen, Taina; Myllyla, Teemu; Kuittinen, Outi; Voipio, Juha 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma. Proper opening of the blood-brain barrier is crucial for the treatment, yet there are no means available for its real-time monitoring. The intact blood-brain barrier maintains a mV-level electrical potential difference between blood and brain tissue, giving rise to a measurable electrical signal at the scalp. Therefore, we... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - CENTRAL-NERVOUS-SYSTEM; PRIMARY CNS LYMPHOMA; SLOW EEG FLUCTUATIONS; DELIVERY; TUMOR; RATS; OSCILLATIONS; PRESERVATION; CHEMOTHERAPY; ANESTHESIA; 3112 Neurosciences; 3122 Cancers 
N1  -   
PP  -  
ER  -