TY  -  
T1  - Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets 
SN  -  /  
UR  - http://hdl.handle.net/10138/230819 
T3  -  
A1  - Veistinen, Lotta K.; Mustonen, Tuija; Hasan, Md. Rakibul; Takatalo, Maarit; Kobayashi, Yukiho; Kesper, Dorthe A.; Vortkamp, Andrea; Rice, David P. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Loss-of-function mutations in GLI3 and IHH cause craniosynostois and reduced osteogeneiss, respectively. In this study, we show that ihh ligand, the receptor Ptch1 and Gli transcription factors are differentialyy expressed in embryonic mouse calvaria osteogenic condenstions. We show that in both ihh(-/-) and Gli3(Xt-J/Xt-J) embroyonic mice, the normal gene expression architecture is lost and this results in disorganized calvarial bone developement. RUNX2 is a master regulatory transciption facto... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - calvarial development; hedgehog signaling pathway; osteoblast; cell differentiation; craniosynostosis; CRANIAL SUTURE MORPHOGENESIS; BONE-DEVELOPMENT; INDIAN-HEDGEHOG; OSTEOBLAST DIFFERENTIATION; EXPRESSION PATTERNS; DIGIT NUMBER; DERMAL BONE; STEM-CELLS; MOUSE; RUNX2; 313 Dentistry; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -