TY  -  
T1  - Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself 
SN  -  /  
UR  - http://hdl.handle.net/10138/317249 
T3  -  
A1  - A, Mu; Fung, Tak Shun; Francomacaro, Lisa M.; Huynh, Thao; Kotila, Tommi; Svindrych, Zdenek; Higgs, Henry N. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - INF2 is a formin protein that accelerates actin polymerization. A common mechanism for formin regulation is autoinhibition, through interaction between the N-terminal diaphanous inhibitory domain (DID) and C-terminal diaphanous autoregulatory domain (DAD). We recently showed that INF2 uses a variant of this mechanism that we term "facilitated autoinhibition," whereby a complex consisting of cyclase-associated protein (CAP) bound to lysine-acetylated actin (KAc-actin) is required for INF2 inhibit... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ADP-ACTIN; COFILIN; CYCLASE-ASSOCIATED PROTEIN; INF2; INVERTED FORMIN 2; LEVEL; MECHANISM; MONOMERS; NUCLEATION; U2OS; WH2 DOMAIN; WH2 motif; cyclase-associated protein; mitochondria; nucleation; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -