TY - T1 - Regulation of Podocyte apoptosis in Diabetic Kidney Disease : Role of SHIP2, PDK1 and CDK2 SN - / UR - URN:ISBN:978-951-51-1809-7; http://hdl.handle.net/10138/159985 T3 - A1 - Saurus, Pauliina A2 - PB - Helsingin yliopisto Y1 - 2016 LA - en AB - Background: Diabetic nephropathy (DN) is a renal complication of diabetes and a common cause of end-stage renal disease (ESRD). DN presents in its earliest stage with low levels of albumin in the urine (microalbuminuria) and develops into overt albuminuria as the disease progresses. Podocyte loss due to detachment or apoptosis has a central role in the pathogenesis of DN, but the mechanisms are not fully understood. The studies in this thesis aimed to increase the knowledge of the pathophysiolog... VO - IS - SP - OP - KW - medicine N1 - PP - ER -