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T1  - Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke : a secondary analysis of an individual patient data meta-analysis 
SN  -  /  
UR  - http://hdl.handle.net/10138/224584 
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A1  - Whiteley, William N.; Emberson, Jonathan; Lees, Kennedy R.; Blackwell, Lisa; Albers, Gregory; Bluhmki, Erich; Brott, Thomas; Cohen, Geoff; Davis, Stephen; Donnan, Geoffrey; Grotta, James; Howard, George; Kaste, Markku; Koga, Masatoshi; von Kummer, Rudiger; Lansberg, Maarten G.; Lindley, Richard I.; Lyden, Patrick; Olivot, Jean Marc; Parsons, Mark; Toni, Danilo; Toyoda, Kazunori; Wahlgren, Nils; Wardlaw, Joanna; del Zoppo, Gregory J.; Sandercock, Peter; Hacke, Werner; Baigent, Colin 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Background Randomised trials have shown that alteplase improves the odds of a good outcome when delivered within 4.5 h of acute ischaemic stroke. However, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the proportional and absolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional impairment in different types of patients. Methods We used individual patient data from the Stroke Thrombolysis Trialists' (STT) meta-analy... 
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KW  - TISSUE-PLASMINOGEN-ACTIVATOR; RANDOMIZED CONTROLLED-TRIAL; INTRAVENOUS THROMBOLYSIS; SYMPTOM ONSET; THERAPY; TENECTEPLASE; THROMBECTOMY; ATLANTIS; ECASS; IST-3; 3124 Neurology and psychiatry 
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