TY  -  
T1  - Role of aryl hydrocarbon receptor (AHR) in overall retinoid metabolism : Response comparisons to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure between wild-type and AHR knockout mice 
SN  -  /  
UR  - http://hdl.handle.net/10138/330134 
T3  -  
A1  - Esteban, Javier; Sánchez-Pérez, Ismael; Hamscher, Gerd; Miettinen, Hanna M.; Korkalainen, Merja; Viluksela, Matti; Pohjanvirta, Raimo; Håkansson, Helen 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Young adult wild-type and aryl hydrocarbon receptor knockout (AHRKO) mice of both sexes and the C57BL/6J background were exposed to 10 weekly oral doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; total dose of 200 ?g/kg bw) to further characterize the observed impacts of AHR as well as TCDD on the retinoid system. Unexposed AHRKO mice harboured heavier kidneys, lighter livers and lower serum all-trans retinoic acid (ATRA) and retinol (REOH) concentrations than wild-type mice. Results from the... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Aryl hydrocarbon receptor; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; Genetically modified organisms; Retinoids; Vitamin A; HEPATIC STELLATE CELLS; ABNORMAL LIVER DEVELOPMENT; TOXIC EQUIVALENCY FACTORS; DIOXIN-INDUCED TOXICITY; SPRAGUE-DAWLEY RATS; VITAMIN-A; GENE-EXPRESSION; ALL-TRANS; COMPARTMENTAL ANALYSIS; AROMATIC-HYDROCARBONS; 1182 Biochemistry, cell and molecular biology; 1184 Genetics, developmental biology, physiology 
N1  -   
PP  -  
ER  -