TY  -  
T1  - Rotavirus vaccine response correlates with the infant gut microbiota composition in Pakistan 
SN  -  /  
UR  - http://hdl.handle.net/10138/237144 
T3  -  
A1  - Harris, Vanessa; Ali, Asad; Fuentes, Susana; Korpela, Katri; Kazi, Momin; Tate, Jacqueline; Parashar, Umesh; Wiersinga, W. Joost; Giaquinto, Carlo; de Weerth, Carolina; de Vos, Willem M. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Rotavirus (RV) is the leading cause of diarrhea-related death in children worldwide and ninety-five percent of rotavirus deaths occur in Africa and Asia. Rotavirus vaccines (RVV) can dramatically reduce RV deaths, but have low efficacy in low-income settings where they are most needed. The intestinal microbiome may contribute to this decreased RVV efficacy. This pilot study hypothesizes that infants' intestinal microbiota composition correlates with RVV immune responses and that RVV responders h... 
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OP  -  
KW  - intestinal microbes; seroconversion; rotavirus vaccine; vaccine immunogenicity; 1ST 2 YEARS; PHYLOGENETIC MICROARRAY; DOUBLE-BLIND; INTESTINAL MICROBIOTA; AFRICAN INFANTS; SECRETOR STATUS; EFFICACY; GASTROENTERITIS; IMMUNOGENICITY; MONOVALENT; 3121 General medicine, internal medicine and other clinical medicine; 1183 Plant biology, microbiology, virology 
N1  -   
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ER  -