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T1  - Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission 
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UR  - http://hdl.handle.net/10138/157014 
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A1  - Arora, Tulika; Velagapudi, Vidya; Pournaras, Dimitri J.; Welbourn, Richard; le Roux, Carel W.; Oresic, Matej; Backhed, Fredrik 
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Y1  - 2015 
LA  - eng 
AB  - Roux-en-Y gastric bypass (RYGB) is an effective method to attain sustained weight loss and diabetes remission. We aimed to elucidate early changes in the plasma metabolome and lipidome after RYGB. Plasma samples from 16 insulin-resistant morbidly obese subjects, of whom 14 had diabetes, were subjected to global metabolomics and lipidomics analysis at pre-surgery and 4 and 42 days after RYGB. Metabolites and lipid species were compared between time points and between subjects who were in remissio... 
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KW  - BARIATRIC SURGERY; BRANCHED-CHAIN; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; OBESE; METABOANALYST; PREVENTION; RESISTANCE; MUSCLE; SERVER; 3121 General medicine, internal medicine and other clinical medicine 
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