TY  -  
T1  - SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub 
SN  -  /  
UR  - http://hdl.handle.net/10138/236580 
T3  -  
A1  - Piazza, Rocco; Magistroni, Vera; Redaelli, Sara; Mauri, Mario; Massimino, Luca; Sessa, Alessandro; Peronaci, Marco; Lalowski, Maciej; Soliymani, Rabah; Mezzatesta, Caterina; Pirola, Alessandra; Banfi, Federica; Rubio, Alicia; Rea, Delphine; Stagno, Fabio; Usala, Emilio; Martino, Bruno; Campiotti, Leonardo; Merli, Michele; Passamonti, Francesco; Onida, Francesco; Morotti, Alessandro; Pavesi, Francesca; Bregni, Marco; Broccoli, Vania; Baumann, Marc; Gambacorti-Passerini, Carlo 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - SETBP1 variants occur as somatic mutations in several hematological malignancies such as atypical chronic myeloid leukemia and as de novo germline mutations in the Schinzel-Giedion syndrome. Here we show that SETBP1 binds to gDNA in AT-rich promoter regions, causing activation of gene expression through recruitment of a HCF1/KMT2A/PHF8 epigenetic complex. Deletion of two AT-hooks abrogates the binding of SETBP1 to gDNA and impairs target gene upregulation. Genes controlled by SETBP1 such as MECO... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ACUTE MYELOID-LEUKEMIA; SCHINZEL-GIEDION SYNDROME; INTEGRATION SITE 1; MYELOMONOCYTIC LEUKEMIA; SECONDARY MUTATIONS; PHF6 MUTATIONS; SELF-RENEWAL; STEM-CELLS; CHIP-SEQ; EXPRESSION; 3111 Biomedicine; 3122 Cancers 
N1  -   
PP  -  
ER  -