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T1  - SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors 
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UR  - http://hdl.handle.net/10138/312610 
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A1  - Lehtonen, Sanna 
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Y1  - 2020 
LA  - eng 
AB  - SHIP2 (Src homology 2 domain-containing inositol 5 '-phosphatase 2) belongs to the family of 5 '-phosphatases. It regulates the phosphoinositide 3-kinase (PI3K)-mediated insulin signalling cascade by dephosphorylating the 5 '-position of PtdIns(3,4,5)P3 to generate PtdIns(3,4)P2, suppressing the activity of the pathway. SHIP2 mouse models and genetic studies in human propose that increased expression or activity of SHIP2 contributes to the pathogenesis of the metabolic syndrome, hypertension and... 
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KW  - diabetes; diabetic kidney disease; insulin resistance; insulin signalling; lipid phosphatase; podocyte; LIPID PHOSPHATASE SHIP2; ACTIVATED PROTEIN-KINASE; INOSITOL 5-PHOSPHATASE SHIP2; ENDOTHELIAL GROWTH-FACTOR; 5'-PHOSPHATASE-2 GENE POLYMORPHISMS; ENDOPLASMIC-RETICULUM STRESS; URINARY ALBUMIN EXCRETION; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; HUMAN PODOCYTES; 3111 Biomedicine; 1184 Genetics, developmental biology, physiology 
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