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T1  - Screening of FDA-Approved Drugs Using a 384-Well Plate-Based Biofilm Platform: The Case of Fingolimod 
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UR  - http://hdl.handle.net/10138/322015 
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A1  - Gilbert-Girard, Shella; Savijoki, Kirsi; Yli-Kauhaluoma, Jari; Fallarero, Adyary 
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PB  - Multidisciplinary Digital Publishing Institute 
Y1  - 2020 
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AB  - In an effort to find new repurposed antibacterial compounds, we performed the screening of an FDA-approved compounds library against <i>Staphylococcus aureus</i> American Type Culture Collection (ATCC) 25923. Compounds were evaluated for their capacity to prevent both planktonic growth and biofilm formation as well as to disrupt pre-formed biofilms. One of the identified initial hits was fingolimod (FTY720), an immunomodulator approved for the treatment of multiple sclerosis, which was then sele... 
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