TY  -  
T1  - Screening of HELQ in breast and ovarian cancer families 
SN  -  /  
UR  - http://hdl.handle.net/10138/223861 
T3  -  
A1  - Pelttari, Liisa M.; Kinnunen, Laura; Kiiski, Johanna I.; Khan, Sofia; Blomqvist, Carl; Aittomaki, Kristiina; Nevanlinna, Heli 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - Several high and moderate risk alleles have been identified for breast and ovarian cancer predisposition and most of them encode proteins that function in DNA repair. A prospective candidate for breast and ovarian cancer susceptibility is the HELQ helicase that has a role in the resolution of DNA interstrand cross-links. HELQ interacts with the RAD51 paralog complex BCDX2. Two components of the complex, RAD51C and RAD51D, increase the risk of ovarian cancer especially, and the other two, RAD51B ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - HELQ; Breast cancer; Ovarian cancer; DNA repair; BRCA2 MUTATIONS; SUSCEPTIBILITY GENE; RAD51 PARALOGS; REPAIR; TUMORIGENESIS; RISK; LOCI; 3122 Cancers 
N1  -   
PP  -  
ER  -