TY  -  
T1  - Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids 
SN  -  /  
UR  - http://hdl.handle.net/10138/325604 
T3  -  
A1  - Kirstgen, Michael; Lowjaga, Kira Alessandra Alicia Theresa; Müller, Simon Franz; Goldmann, Nora; Lehmann, Felix; Alakurtti, Sami; Yli-Kauhaluoma, Jari; Klebe, Dieter; Geyer, Joachim 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses in 2012 enables target-based development of HBV/HDV cell-entry inhibitors. Many studies already identified appropriate NTCP inhibitors. However, most of them interfere with NTCP's physiological function as a hepatic bile acid transporter. To overcome this draw... 
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IS  -  
SP  -  
OP  -  
KW  - 11832 Microbiology and virology; 317 Pharmacy; COTRANSPORTING POLYPEPTIDE NTCP; BILE-ACID TRANSPORTER; MEMBRANE TRANSPORTER; CYCLOSPORINE-A; CELL-LINES; IN-VITRO; DERIVATIVES; INFECTION; IDENTIFICATION; HEPATOCYTES 
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ER  -