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T1  - Semi-synthetic puwainaphycin/minutissamide cyclic lipopeptides with improved antifungal activity and limited cytotoxicity 
SN  -  /  
UR  - http://hdl.handle.net/10138/336658 
T3  -  
A1  - Hajek, Jan; Bieringer, Sebastian; Voracova, Katerina; Macho, Marketa; Saurav, Kumar; Delawska, Katerina; Divoka, Petra; Fiser, Radovan; Mikusova, Gabriela; Cheel, Jose; Fewer, David P.; Vu, Dai Long; Paichlova, Jindriska; Riepl, Herbert; Hrouzek, Pavel 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Microbial cyclic lipopeptides are an important class of antifungal compounds with applications in pharmacology and biotechnology. However, the cytotoxicity of many cyclic lipopeptides limits their potential as antifungal drugs. Here we present a structure-activity relationship study on the puwainaphycin/minutissamide (PUW/MIN) family of cyclic lipopeptides isolated from cyanobacteria. PUWs/MINs with variable fatty acid chain lengths differed in the dynamic of their cytotoxic effect despite their... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - ALGA ANABAENA-LAXA; MEMBRANE PERMEABILIZATION; LAXAPHYCIN-B; PEPTIDES; TRICHORMAMIDES; INHIBITION; ITURINS; 1182 Biochemistry, cell and molecular biology 
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ER  -