TY  -  
T1  - Shared PKS Module in Biosynthesis of Synergistic Laxaphycins 
SN  -  /  
UR  - http://hdl.handle.net/10138/320549 
T3  -  
A1  - Heinilä, Lassi; Fewer, David; Jokela, Jouni; Wahlsten, Matti; Jortikka, Anna Elisabeth; Sivonen, Kaarina 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Cyanobacteria produce a wide range of lipopeptides that exhibit potent membrane-disrupting activities. Laxaphycins consist of two families of structurally distinct macrocyclic lipopeptides that act in a synergistic manner to produce antifungal and antiproliferative activities. Laxaphycins are produced by range of cyanobacteria but their biosynthetic origins remain unclear. Here, we identified the biosynthetic pathways responsible for the biosynthesis of the laxaphycins produced by Scytonema hofm... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 11832 Microbiology and virology; Synergy; Biosynthesis; Dehydrobutyrine; Natural Product; Cupin; Laxaphycin; Scytocyclamide; Antifungal; synergy; biosynthesis; natural product; laxaphycin; scytocyclamide; antifungal; cupin; dehydrobutyrine; NONRIBOSOMAL PEPTIDE SYNTHETASES; ANTIFUNGAL CYCLIC-PEPTIDES; ALGA ANABAENA-LAXA; GENE-CLUSTER; NATURAL-PRODUCTS; CYANOBACTERIA; LIPOPEPTIDES; ANABAENOPEPTIN; TRICHORMAMIDES; IDENTIFICATION 
N1  -   
PP  -  
ER  -