TY - T1 - Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib SN - / UR - http://hdl.handle.net/10138/212972 T3 - A1 - Gullaksen, Stein-Erik; Skavland, Jorn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Tobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjorn Tore A2 - PB - Y1 - 2017 LA - eng AB - Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukemia. Changes in phosphorylated Bcr-Abl1 and the signaling pathways involved ... VO - IS - SP - OP - KW - CHRONIC MYELOGENOUS LEUKEMIA; KINASE INHIBITOR THERAPY; BCR-ABL; MOLECULAR RESPONSE; IMATINIB; PHOSPHOPROTEIN; ACTIVATION; REGULATORS; DASATINIB; CORRELATE; 3122 Cancers N1 - PP - ER -