TY  -  
T1  - Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib 
SN  -  /  
UR  - http://hdl.handle.net/10138/212972 
T3  -  
A1  - Gullaksen, Stein-Erik; Skavland, Jorn; Gavasso, Sonia; Tosevski, Vinko; Warzocha, Krzysztof; Dumrese, Claudia; Ferrant, Augustin; Gedde-Dahl, Tobias; Hellmann, Andrzej; Janssen, Jeroen; Labar, Boris; Lang, Alois; Majeed, Waleed; Mihaylov, Georgi; Stentoft, Jesper; Stenke, Leif; Thaler, Josef; Thielen, Noortje; Verhoef, Gregor; Voglova, Jaroslava; Ossenkoppele, Gert; Hochhaus, Andreas; Hjorth-Hansen, Henrik; Mustjoki, Satu; Sopper, Sieghart; Giles, Francis; Porkka, Kimmo; Wolf, Dominik; Gjertsen, Bjorn Tore 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Monitoring of single cell signal transduction in leukemic cellular subsets has been proposed to provide deeper understanding of disease biology and prognosis, but has so far not been tested in a clinical trial of targeted therapy. We developed a complete mass cytometry analysis pipeline for characterization of intracellular signal transduction patterns in the major leukocyte subsets of chronic phase chronic myeloid leukemia. Changes in phosphorylated Bcr-Abl1 and the signaling pathways involved ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - CHRONIC MYELOGENOUS LEUKEMIA; KINASE INHIBITOR THERAPY; BCR-ABL; MOLECULAR RESPONSE; IMATINIB; PHOSPHOPROTEIN; ACTIVATION; REGULATORS; DASATINIB; CORRELATE; 3122 Cancers 
N1  -   
PP  -  
ER  -