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T1  - Sleep-State Dependent Alterations in Brain Functional Connectivity under Urethane Anesthesia in a Rat Model of Early-Stage Parkinson's Disease 
SN  -  /  
UR  - http://hdl.handle.net/10138/311287 
T3  -  
A1  - Zhurakovskaya, Ekaterina; Leikas, Juuso; Pirttimaki, Tiina; Mon, Francesc Casas; Gynther, Mikko; Aliev, Rubin; Rantamaki, Tomi; Tanila, Heikki; Forsberg, Markus M.; Gröhn, Olli; Paasonen, Jaakko; Jalkanen, Aaro J. 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Parkinson's disease (PD) is characterized by the gradual degeneration of dopaminergic neurons in the substantia nigra, leading to striatal dopamine depletion. A partial unilateral striatal 6-hydroxydopamine (6-OHDA) lesion causes 40-60% dopamine depletion in the lesioned rat striatum, modeling the early stage of PD. In this study, we explored the connectivity between the brain regions in partially 6-OHDA lesioned male Wistar rats under urethane anesthesia using functional magnetic resonance imag... 
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KW  - 6-OHDA lesion; connectivity; rat; resting-state fMRI; sleep; urethane; MAGNETIC-RESONANCE SPECTROSCOPY; BEHAVIOR DISORDER; REM-SLEEP; DOPAMINE; STRIATUM; LESIONS; 6-HYDROXYDOPAMINE; DEGENERATION; ACTIVATION; GLUTAMATE; 3124 Neurology and psychiatry 
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ER  -