TY  -  
T1  - Small-Molecule Ligands that Bind the RET Receptor Activate Neuroprotective Signals Independent of but Modulated by Coreceptor GFR alpha 1 
SN  -  /  
UR  - http://hdl.handle.net/10138/332075 
T3  -  
A1  - Jmaeff, Sean; Sidorova, Yulia; Lippiatt, Hayley; Barcelona, Pablo F.; Nedev, Hinyu; Saragovi, Lucia M.; Hancock, Mark A.; Saarma, Mart; Saragovi, H. Uri 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Glial cell line-derived neurotrophic factor (GDNF) binds the GFR alpha 1 receptor, and the GDNF-GFR alpha 1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways. To dissect the GDNF-GFR alpha 1-RET signaling complex, agents that bind and activate RET directly and independently of GFR alpha 1 expression are valuable tools. In a focused naphthalenesulfonic acid library from the National Cancer Institute database, we identified small ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - NEUROTROPHIC FACTOR GDNF; TYROSINE KINASE; RAT MODEL; FAMILY; TRKA; GROWTH; DEGENERATION; NEUROPATHY; MECHANISM; NEURTURIN; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -