TY  -  
T1  - Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health 
SN  -  /  
UR  - http://hdl.handle.net/10138/258656 
T3  -  
A1  - Tsai, Pei-Chien; Glastonbury, Craig A.; Eliot, Melissa N.; Bollepalli, Sailalitha; Yet, Idil; Castillo-Fernandez, Juan E.; Carnero-Montoro, Elena; Hardiman, Thomas; Martin, Tiphaine C.; Vickers, Alice; Mangino, Massimo; Ward, Kirsten; Pietilaeinen, Kirsi H.; Deloukas, Panos; Spector, Tim D.; Vinuela, Ana; Loucks, Eric B.; Ollikainen, Miina; Kelsey, Karl T.; Small, Kerrin S.; Bell, Jordana T. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Background: Tobacco smoking is a risk factor for multiple diseases, including cardiovascular disease and diabetes. Many smoking-associated signals have been detected in the blood methylome, but the extent to which these changes are widespread to metabolically relevant tissues, and impact gene expression or metabolic health, remains unclear. Methods: We investigated smoking-associated DNA methylation and gene expression variation in adipose tissue biopsies from 542 healthy female twins. Replicati... 
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KW  - Smoking; DNA methylation; Gene expression; RNA-sequencing; Adipose tissue; EPIGENOME-WIDE ASSOCIATION; MESSENGER-RNA EXPRESSION; CIGARETTE-SMOKING; TOBACCO-SMOKING; GENOTYPE IMPUTATION; MATERNAL SMOKING; AHRR METHYLATION; HUMAN GENOME; LUNG-CANCER; LOCI; 3122 Cancers; 3142 Public health care science, environmental and occupational health; 3111 Biomedicine 
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