TY  -  
T1  - Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis 
SN  -  /  
UR  - http://hdl.handle.net/10138/212620 
T3  -  
A1  - Savola, P.; Kelkka, T.; Rajala, H. L.; Kuuliala, A.; Kuuliala, K.; Eldfors, S.; Ellonen, P.; Lagstrom, S.; Lepisto, M.; Hannunen, T.; Andersson, E. I.; Khajuria, R. K.; Jaatinen, T.; Koivuniemi, R.; Repo, H.; Saarela, J.; Porkka, K.; Leirisalo-Repo, M.; Mustjoki, S. 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been investigated. Here, we show that patients with newly diagnosed rheumatoid arthritis have expanded CD8(+) T-cell clones; in 20% (5/25) of patients CD8(+) T cells, but not CD4(+) T cells, harbour somatic mutations. In healthy controls (n = 20), only one mutation is identified in the CD8(+) T-cell p... 
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IS  -  
SP  -  
OP  -  
KW  - PROTEIN FUNCTION; CELL REPERTOIRE; ELDERLY INDIVIDUALS; STAT3 MUTATIONS; INNATE IMMUNITY; HEMATOPOIESIS; BLOOD; EXPANSIONS; LEUKEMIA; CANCER; 3122 Cancers; 3121 General medicine, internal medicine and other clinical medicine 
N1  -   
PP  -  
ER  -