TY  -  
T1  - Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation 
SN  -  /  
UR  - http://hdl.handle.net/10138/161430 
T3  -  
A1  - Solman, Maja; Ligabue, Alessio; Blazevits, Olga; Jaiswal, Alok; Zhou, Yong; Liang, Hong; Lectez, Benoit; Kopra, Kari; Guzman, Camilo; Harma, Harri; Hancock, John F.; Aittokallio, Tero; Abankwa, Daniel 
A2  -  
PB  -  
Y1  - 2015 
LA  - eng 
AB  - Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. Here, we show that several cancer-associated mutations in the switch III region moderately increase Ras activity in all isoforms. Mutants are biochemically inconspicuous, while their clustering into nanoscale signaling complexes on the plasma membrane,... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - H-RAS; K-RAS; PLASMA-MEMBRANE; DEVELOPMENTAL DISORDERS; QUANTITATIVE-ANALYSIS; SIGNAL-TRANSDUCTION; PROTEIN-KINASE; FORMS DIMERS; NUCLEOTIDE; ORIENTATION; 3111 Biomedicine; 3122 Cancers 
N1  -   
PP  -  
ER  -