TY  -  
T1  - Spermatogonial quantity in human prepubertal testicular tissue collected for fertility preservation prior to potentially sterilizing therapy 
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UR  - http://hdl.handle.net/10138/288214 
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A1  - Stukenborg, J. -B.; Alves-Lopes, J. P.; Kurek, M.; Albalushi, H.; Reda, A.; Keros, V.; Töhönen, V.; Bjarnason, R.; Romerius, P.; Sundin, M.; Nyström, U. Noren; Langenskiöld, C.; Vogt, H.; Henningsohn, L.; Mitchell, R. T.; Söder, O.; Petersen, C.; Jahnukainen, K. 
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PB  -  
Y1  - 2018 
LA  - eng 
AB  - STUDY QUESTION: Does chemotherapy exposure (with or without alkylating agents) or primary diagnosis affect spermatogonial quantity in human prepubertal testicular tissue? SUMMARY ANSWER: Spermatogonial quantity is significantly reduced in testes of prepubertal boys treated with alkylating agent therapies or with hydroxyurea for sickle cell disease. WHAT IS KNOWN ALREADY: Cryopreservation of spermatogonial stem cells, followed by transplantation into the testis after treatment, is a proposed clin... 
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KW  - fertility preservation; childhood cancer; sickle cell disease; alkylating agents; spermatogonial quantity; SICKLE-CELL-DISEASE; CANCER-TREATMENT; WORKING PARTY; CHILDHOOD; CHILDREN; HYDROXYUREA; CRYOPRESERVATION; TRANSPLANTATION; ADOLESCENTS; EBMT; 3123 Gynaecology and paediatrics 
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