TY - T1 - Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems SN - / UR - http://hdl.handle.net/10138/166978 T3 - A1 - Gillespie, Joseph J.; Phan, Isabelle Q. H.; Scheib, Holger; Subramanian, Sandhya; Edwards, Thomas E.; Lehman, Stephanie S.; Piitulainen, Hanna; Rahman, M. Sayeedur; Rennoll-Bankert, Kristen E.; Staker, Bart L.; Taira, Suvi; Stacy, Robin; Myler, Peter J.; Azad, Abdu F.; Pulliainen, Arto T. A2 - PB - Y1 - 2015 LA - eng AB - Prokaryotes use type IV secretion systems (T4SSs) to translocate substrates (e.g., nucleoprotein, DNA, and protein) and/or elaborate surface structures (i.e., pili or adhesins). Bacterial genomes may encode multiple T4SSs, e.g., there are three functionally divergent T4SSs in some Bartonella species (vir, vbh, and trw). In a unique case, most rickettsial species encode a T4SS (rvh) enriched with gene duplication. Within single genomes, the evolutionary and functional implications of cross-system... VO - IS - SP - OP - KW - ESSENTIAL VIRULENCE PROTEIN; TRIPHOSPHATE-BINDING DOMAIN; HELICOBACTER-PYLORI; AGROBACTERIUM-TUMEFACIENS; LEGIONELLA-PNEUMOPHILA; BRUCELLA-SUIS; CORE COMPLEX; PHYLOGENETIC RECONSTRUCTION; TRANSFORMATION COMPETENCE; INFECTIOUS-DISEASE; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -