TY - T1 - Synchronous spiking associated with prefrontal high y oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus SN - / UR - http://hdl.handle.net/10138/342624 T3 - A1 - Totah, Nelson K.; Logothetis, Nikos K.; Eschenko, Oxana A2 - PB - Y1 - 2021 LA - eng AB - The brainstem noradrenergic locus coeruleus (LC) is reciprocally connected with the prefrontal cortex (PFC). Coupling between LC spiking and the depolarizing phase of slow (1?2 Hz) waves in PFC field potentials during sleep and anesthesia suggests that LC drives cortical state transition. Reciprocal LC-PFC connectivity should also allow interactions in the opposing (top-down) direction, but prior work has only studied prefrontal control over LC activity using electrical or optogenetic stimulatio... VO - IS - SP - OP - KW - y; locus coeruleus; synchrony; 0; top-down control; NORADRENERGIC NEURONS; GAMMA OSCILLATIONS; CORTEX; RAT; PROJECTIONS; DYNAMICS; ORGANIZATION; INNERVATION; SYSTEM; HZ; 3112 Neurosciences N1 - PP - ER -