TY - T1 - Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway SN - / UR - http://hdl.handle.net/10138/329024 T3 - A1 - Chronopoulos, Antonios; Thorpe, Stephen D.; Cortes, Ernesto; Lachowski, Dariusz; Rice, Alistair J.; Mykuliak, Vasyl V.; Rog, Tomasz; Lee, David A.; Hytönen, Vesa P.; Hernandez, Armando E. del Rio A2 - PB - Y1 - 2020 LA - eng AB - A mechanism of cell response to localized tension shows that syndecan-4 synergizes with EGFR to elicit a mechanosignalling cascade that leads to adaptive cell stiffening through PI3K/kindlin-2 mediated integrin activation. Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via a coord... VO - IS - SP - OP - KW - HEPARAN-SULFATE PROTEOGLYCANS; EPIDERMAL-GROWTH-FACTOR; MOLECULAR-DYNAMICS; ALPHA-ACTININ; PKC-ALPHA; FOCAL ADHESIONS; FORCE; MIGRATION; RECEPTOR; BINDING; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -