TY  -  
T1  - Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway 
SN  -  /  
UR  - http://hdl.handle.net/10138/329024 
T3  -  
A1  - Chronopoulos, Antonios; Thorpe, Stephen D.; Cortes, Ernesto; Lachowski, Dariusz; Rice, Alistair J.; Mykuliak, Vasyl V.; Rog, Tomasz; Lee, David A.; Hytönen, Vesa P.; Hernandez, Armando E. del Rio 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - A mechanism of cell response to localized tension shows that syndecan-4 synergizes with EGFR to elicit a mechanosignalling cascade that leads to adaptive cell stiffening through PI3K/kindlin-2 mediated integrin activation. Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical cues. We reveal here a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via a coord... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - HEPARAN-SULFATE PROTEOGLYCANS; EPIDERMAL-GROWTH-FACTOR; MOLECULAR-DYNAMICS; ALPHA-ACTININ; PKC-ALPHA; FOCAL ADHESIONS; FORCE; MIGRATION; RECEPTOR; BINDING; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -