TY  -  
T1  - Synthesis, Characterization, and Biological Properties of Steroidal Ruthenium(II) and Iridium(111) Complexes Based on the Androst-16-en-3-ol Framework 
SN  -  /  
UR  - http://hdl.handle.net/10138/321395 
T3  -  
A1  - Koch, Vanessa; Meschkov, Anna; Feuerstein, Wolfram; Pfeifer, Juliana; Fuhr, Olaf; Nieger, Martin; Schepers, Ute; Bräse, Stefan 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - A range of novel cyclometalated ruthenium(II) and iridium(III) complexes with a steroidal backbone based on androsterone were synthesized and characterized by NMR spectroscopy and X-ray crystallography. Their cytotoxic properties in RT112 and RT112 cP (cisplatin-resistant) cell lines as well as in MCF7 and somatic fibroblasts were compared with those of the corresponding nonsteroidal complexes and the noncyclometalated pyridyl complexes as well as with cisplatin as reference. All steroidal compl... 
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KW  - H BOND ACTIVATION; PHASE-I; ESCHERICHIA-COLI; CELL-DIVISION; NAMI-A; ANTICANCER; CANCER; DNA; APPROXIMATION; OXALIPLATIN; 116 Chemical sciences; 1182 Biochemistry, cell and molecular biology 
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