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T1  - Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors 
SN  -  /  
UR  - http://hdl.handle.net/10138/313633 
T3  -  
A1  - Ahonen, Tiina J.; Rinne, Maiju; Grutschreiber, Peter; Mätlik, Kert; Airavaara, Mikko; Schaarschmidt, Dieter; Lang, Heinrich; Reiss, David; Xhaard, Henri; Gaveriaux-Ruff, Claire; Yli-Kauhaluoma, Jari; Moreira, Vania M. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Despite extensive years of research, the direct oxidation of the 7,8-double bond of opioids has so far received little attention and knowledge about the effects of this modification on activity at the different opioid receptors is scarce. We herein report that potassium permanganate supported on iron(II) sulfate heptahydrate can be used as a convenient oxidant in the one-step, heterogeneous conversion of Delta(7.8)-opioids to the corresponding 7 beta-hydroxy-8-ketones. Details of the reaction me... 
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KW  - Morphine; Oxidation; Supported permanganate; Hydroxy ketone; Antagonist; Opioid receptor; HETEROGENEOUS PERMANGANATE OXIDATIONS; POTASSIUM-PERMANGANATE; SUPPORTED PERMANGANATE; BINDING-PROPERTIES; ORGANIC-COMPOUNDS; MORPHINE ANALOGS; OXIDIZING-AGENT; CODEINE; ACTIVATION; EFFICIENT; 317 Pharmacy 
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