TY  -  
T1  - Synthesis of quinone-based heterocycles of broad-spectrum anticancer activity 
SN  -  /  
UR  - http://hdl.handle.net/10138/332763 
T3  -  
A1  - Aly, Ashraf A.; Hassan, Alaa A.; Mohamed, Nasr K.; Ramadan, Mohamed; Abd El-Aal, Amal S.; Braese, Stefan; Nieger, Martin 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - A synthesis of benzo[e][1,2,4]triazines and 1,2,4-triazolospiro[4,5]deca-2,6,9-trien-8-ones has been developed from reactions of amidrazones with 2-chloro-1,4-benzoquinone in EtOAc containing 0.5 mL of piperidine. This highly regioselective and one-pot process provided rapid access to 1,2,4-triazolospiro[4,5]deca-2,6,9-trien-8-ones (60%-70%) and benzo[e][1,2,4]triazines (11%-18%). On reacting amidrazones with 5-hydroxy-1,4-naphthoquinone in an EtOAc/piperidine mixture, the reaction proceeded to ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 116 Chemical sciences; 1; 2; 4-triazolospiro[4; 5]deca-2; 6; 9-trien-8-ones; 2-chloro-1; 4-benzoquinone; 5-hydroxy-1; 4-naphthoquinone; 5-hydroxy-2-(piperidin-1-yl)naphthalene-1; 4-dione; amidrazones; benzo[e][1; 4]triazines; NAPHTHOQUINONE DERIVATIVES; ANTIMALARIAL ACTIVITY; ANTITUMOR AGENTS; AMIDRAZONES; CANCER 
N1  -   
PP  -  
ER  -