TY  -  
T1  - Systematic mapping of cancer cell target dependencies using high-throughput drug screening in triple-negative breast cancer 
SN  -  /  
UR  - http://hdl.handle.net/10138/325869 
T3  -  
A1  - Wang, Tianduanyi; Gautam, Prson; Rousu, Juho; Aittokallio, Tero 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - While high-throughput drug screening offers possibilities to profile phenotypic responses of hundreds of compounds, elucidation of the cell context-specific mechanisms of drug action requires additional analyses. To that end, we developed a computational target deconvolution pipeline that identifies the key target dependencies based on collective drug response patterns in each cell line separately. The pipeline combines quantitative drug-cell line responses with drug-target interaction networks ... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Target addiction; Cancer vulnerability; Functional dependency; Gene essentiality; Drug screening; Multi-targeted treatments; EXPRESSION; POLYPHARMACOLOGY; DECONVOLUTION; OPPORTUNITIES; SENSITIVITY; CHALLENGES; ADDICTION; EFFICACY; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -