TY  -  
T1  - Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors : Results from a Phase I/II Clinical Trial 
SN  -  /  
UR  - http://hdl.handle.net/10138/334630 
T3  -  
A1  - Virtakoivu, Reetta; Rannikko, Jenna H.; Viitala, Miro; Vaura, Felix; Takeda, Akira; Lonnberg, Tapio; Koivunen, Jussi; Jaakkola, Panu; Pasanen, Annika; Shetty, Shishir; de Jonge, Maja J. A.; Robbrecht, Debbie; Ma, Yuk Ting; Skyttä, Tanja; Minchom, Anna; Jalkanen, Sirpa; Karvonen, Matti K.; Mandelin, Jami; Bono, Petri; Hollmen, Maija 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Purpose: Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell-targeting therapies. Thus, agents able to reprogram macrophages toward a proinflammatory state hold promise as novel immunotherapies for solid cancers. Inhibition of the macrophage scavenger receptor Clever-1 has shown benefit in inducing CD8 T-cell-mediated antitumor responses in mouse models of cancer, which supports the clinical development of Clever-1-targeting ant... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - DENDRITIC CELLS; T-CELLS; RECEPTOR; MACROPHAGES; DIFFERENTIATION; HOMEOSTASIS; ENVIRONMENT; STABILIN-1; PATHWAYS; 3122 Cancers 
N1  -   
PP  -  
ER  -