TY - T1 - Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis : effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight SN - / UR - http://hdl.handle.net/10138/328262 T3 - A1 - Heiskanen, Marja A.; Honkala, Sanna M.; Hentila, Jaakko; Ojala, Ronja; Lautamäki, Riikka; Koskensalo, Kalle; Lietzen, Martin S.; Saunavaara, Virva; Saunavaara, Jani; Helmiö, Mika; Loyttyniemi, Eliisa; Nummenmaa, Lauri; Collado, Maria C.; Malm, Tarja; Lahti, Leo; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Rinne, Juha O.; Hannukainen, Jarna C. A2 - PB - Y1 - 2021 LA - eng AB - Background: Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between the central nervous system, peripheral tissues, and gut microbiota, and is affected by genetics. Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS) aims to gain new systems-level understanding of the cen... VO - IS - SP - OP - KW - Obesity; Insulin resistance; Type 2 diabetes; Exercise training; Glucose metabolism; Brain metabolism; Monozygotic twins; 3121 General medicine, internal medicine and other clinical medicine N1 - PP - ER -