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T1  - TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells 
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UR  - http://hdl.handle.net/10138/331873 
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A1  - Ranta-aho, Sofia; Piippo, Niina; Korhonen, Eveliina; Kaarniranta, Kai; Hytti, Maria; Kauppinen, Anu 
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PB  -  
Y1  - 2021 
LA  - eng 
AB  - Chronic inflammation has been associated with several chronic diseases, such as age-related macular degeneration (AMD). The NLRP3 inflammasome is a central proinflammatory signaling complex that triggers caspase-1 activation leading to the maturation of IL-1 beta. We have previously shown that the inhibition of the chaperone protein, Hsp90, prevents NLRP3 activation in human retinal pigment epithelial (RPE) cells; these are cells which play a central role in the pathogenesis of AMD. In that stud... 
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KW  - NLRP3; Hsp90; TAS-116; age-related macular degeneration; retinal pigment epithelium; 1ST-IN-HUMAN PHASE-I; SHOCK-PROTEIN 90; MACULAR DEGENERATION; REDUCES INFLAMMATION; THERAPEUTIC INDEX; ARPE-19; CYTOTOXICITY; DEGRADATION; INDUCTION; PATHWAYS; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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