TY  -  
T1  - TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin 
SN  -  /  
UR  - http://hdl.handle.net/10138/329236 
T3  -  
A1  - Balestra, Fernando R.; Dominguez-Calvo, Andres; Wolf, Benita; Busso, Coralie; Buff, Alizee; Averink, Tessa; Lipsanen-Nyman, Marita; Huertas, Pablo; Rios, Rosa M.; Gönczy, Pierre 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we characterize these centriolar protein assemblies (Cenpas) to uncover the mechanism of action of TRIM37. We find that an atypical de novo assembly pathway can generate Cenpas that act as microtubule-organizing centers (MTOCs), including in Mulibrey p... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - COILED-COIL PROTEIN; DE-NOVO; MICROTUBULE NUCLEATION; SINGLE PROCENTRIOLE; DAUGHTER CENTRIOLES; MULIBREY NANISM; POLO KINASE; CENTROSOME; PLK4; CELLS; 3123 Gynaecology and paediatrics; 3122 Cancers 
N1  -   
PP  -  
ER  -