TY  -  
T1  - TRPV Protein Family-From Mechanosensing to Cancer Invasion 
SN  -  /  
UR  - http://hdl.handle.net/10138/332866 
T3  -  
A1  - Karki, Tytti; Tojkander, Sari 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Biophysical cues from the cellular microenvironment are detected by mechanosensitive machineries that translate physical signals into biochemical signaling cascades. At the crossroads of extracellular space and cell interior are located several ion channel families, including TRP family proteins, that are triggered by mechanical stimuli and drive intracellular signaling pathways through spatio-temporally controlled Ca2+-influx. Mechanosensitive Ca2+-channels, therefore, act as critical component... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - TRPV; mechanosensing; cancer; invasion; POTENTIAL VANILLOID 2; CATION CHANNEL TRPV4; ION-CHANNEL; PROSTATE-CANCER; TUMOR-GROWTH; CAPSAICIN-RECEPTOR; CA2+ INFLUX; OSMOSENSORY TRANSDUCTION; CLINICAL-SIGNIFICANCE; THERAPEUTIC TARGET; 1182 Biochemistry, cell and molecular biology 
N1  -   
PP  -  
ER  -