TY  -  
T1  - Tandem-Mass-Tag based proteomic analysis facilitates analyzing critical factors of porous silicon nanoparticles in determining their biological responses under diseased condition 
SN  -  /  
UR  - http://hdl.handle.net/10138/318168 
T3  -  
A1  - Li, Yunzhan; Liu, Zehua; Li, Li; Lian, Wenhua; He, Yaohui; Khalil, Elbadry; Makila, Ermei; Zhang, Wenzhong; Torrieri, Giulia; Liu, Xueyan; Su,  Jingyi; Xiu, Yuanming; Fontana, Flavia; Salonen, Jarno; Hirvonen, Jouni; Liu, Wen; Zhang, Hongbo; Santos, Hélder A.; Deng, Xianming 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - The analysis of nanoparticles' biocompatibility and immunogenicity is mostly performed under a healthy condition. However, more clinically relevant evaluation conducted under pathological condition is less known. Here, the immunogenicity and bio-nano interactions of porous silicon nanoparticles (PSi NPs) are evaluated in an acute liver inflammation mice model. Interestingly, a new mechanism in which PSi NPs can remit the hepatocellular damage and inflammation activation in a surface dependent ma... 
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IS  -  
SP  -  
OP  -  
KW  - BIOCOMPATIBILITY; BLOOD; FIBRILLATION; IRON-OXIDE NANOPARTICLES; MECHANISMS; OXIDATION; PROTEIN CORONA; R-language; RELEASE; SURFACE; TUMOR-GROWTH; acute liver inflammation; immunogenicity; porous silicon; protein corona; 116 Chemical sciences; 317 Pharmacy 
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ER  -