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T1  - Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice 
SN  -  /  
UR  - http://hdl.handle.net/10138/318892 
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A1  - Wang, Hong; Kuusela, Sara; Rinnankoski-Tuikka, Rita; Dumont, Vincent; Bouslama, Rim; Ramadan, Usama Abo; Waaler, Jo; Linden, Anni-Maija; Chi, Nai-Wen; Krauss, Stefan; Pirinen, Eija; Lehtonen, Sanna 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Objective Human TNKS, encoding tankyrase 1 (TNKS1), localizes to a susceptibility locus for obesity and type 2 diabetes mellitus (T2DM). Here, we addressed the therapeutic potential of G007-LK, a TNKS-specific inhibitor, for obesity and T2DM. Methods We administered G007-LK to diabetic db/db mice and measured the impact on body weight, abdominal adiposity, and serum metabolites. Muscle, liver, and white adipose tissues were analyzed by quantitative RT-PCR and western blotting to determine TNKS i... 
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KW  - FATTY-ACID OXIDATION; RECEPTOR COACTIVATOR PGC-1-ALPHA; BETA-CELL FUNCTION; SKELETAL-MUSCLE; GLUCOSE-METABOLISM; ADIPOSE-TISSUE; PHARMACOLOGICAL INHIBITION; HEPATIC GLUCONEOGENESIS; MITOCHONDRIAL-FUNCTION; PGC-1 COACTIVATORS; 3121 General medicine, internal medicine and other clinical medicine; 3143 Nutrition 
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