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T1  - Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding 
SN  -  /  
UR  - http://hdl.handle.net/10138/223955 
T3  -  
A1  - Bjorkgren, Ida; Alvarez, Luis; Blank, Nelli; Balbach, Melanie; Turunen, Heikki; Laajala, Teemu Daniel; Toivanen, Jussi; Krutskikh, Anton; Wahlberg, Niklas; Huhtaniemi, Ilpo; Poutanen, Matti; Wachten, Dagmar; Sipila, Petra 
A2  -  
PB  -  
Y1  - 2016 
LA  - eng 
AB  - During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in the epididymis, continue to regulate sperm motility during capacitation and hyperactivation in the female reproductive tract. We characterized the mouse beta-defensin 41 (DEFB41), by generating a mouse model with iCre recombinase inserted into the first exon of the gene. The homozygous Defb41(iCre/iCre) knock-in mic... 
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KW  - Beta-defensin; Epididymis; Sperm maturation; Flagellar motility pattern; Sperm-oocyte binding; iCre knock-in; TYROSINE PHOSPHORYLATION; HYPERACTIVATED MOTILITY; RAT SPERMATOZOA; MALE-FERTILITY; MOVEMENT CHARACTERISTICS; REPRODUCTIVE-TRACT; GENE CLUSTERS; PROTEIN; CAPACITATION; MICE; 1182 Biochemistry, cell and molecular biology 
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ER  -