TY - T1 - Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding SN - / UR - http://hdl.handle.net/10138/223955 T3 - A1 - Bjorkgren, Ida; Alvarez, Luis; Blank, Nelli; Balbach, Melanie; Turunen, Heikki; Laajala, Teemu Daniel; Toivanen, Jussi; Krutskikh, Anton; Wahlberg, Niklas; Huhtaniemi, Ilpo; Poutanen, Matti; Wachten, Dagmar; Sipila, Petra A2 - PB - Y1 - 2016 LA - eng AB - During epididymal maturation, sperm acquire the ability to swim progressively by interacting with proteins secreted by the epididymal epithelium. Beta-defensin proteins, expressed in the epididymis, continue to regulate sperm motility during capacitation and hyperactivation in the female reproductive tract. We characterized the mouse beta-defensin 41 (DEFB41), by generating a mouse model with iCre recombinase inserted into the first exon of the gene. The homozygous Defb41(iCre/iCre) knock-in mic... VO - IS - SP - OP - KW - Beta-defensin; Epididymis; Sperm maturation; Flagellar motility pattern; Sperm-oocyte binding; iCre knock-in; TYROSINE PHOSPHORYLATION; HYPERACTIVATED MOTILITY; RAT SPERMATOZOA; MALE-FERTILITY; MOVEMENT CHARACTERISTICS; REPRODUCTIVE-TRACT; GENE CLUSTERS; PROTEIN; CAPACITATION; MICE; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -