TY  -  
T1  - Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A 
SN  -  /  
UR  - http://hdl.handle.net/10138/326607 
T3  -  
A1  - Kazemi, Soheila; Kawaguchi, Shinsaku; Badr, Christian E.; Mattos, Daphne R.; Ruiz-Saenz, Ana; Serrill, Jeffrey D.; Moasser, Mark M.; Dolan, Brian P.; Paavilainen, Ville O.; Oishi, Shinya; McPhail, Kerry L.; Ishmael, Jane E. 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Coibamide A is a potent cancer cell toxin and one of a select group of natural products that inhibit protein entry into the secretory pathway via a direct inhibition of the Sec61 protein translocon. Many Sec61 client proteins are clinically relevant drug targets once trafficked to their final destination in or outside the cell, however the use of Sec61 inhibitors to block early biosynthesis of specific proteins is at a pre-clinical stage. In the present study we evaluated the action of coibamide... 
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KW  - ErbB; HER; Signal peptide; Kinase inhibitor; Coibamide A; Apratoxin A; EPIDERMAL-GROWTH-FACTOR; FACTOR-RECEPTOR MUTATIONS; PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL EVALUATION; ERBB RECEPTORS; CANCER-THERAPY; BREAST-CANCER; TRANSLOCATION; POTENT; SUBSTRATE; 1182 Biochemistry, cell and molecular biology; 317 Pharmacy 
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