TY  -  
T1  - Targeting prospero homeobox 1 (Prox1) transcription factor in rhabdomyosarcoma 
SN  -  /  
UR  - URN:NBN:fi:hulib-201907173187; http://hdl.handle.net/10138/303936 
T3  -  
A1  - Punger, Tatjana 
A2  -  
PB  - Helsingin yliopisto 
Y1  - 2017 
LA  - eng 
AB  - Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. It arises from skeletal muscle stem cells, which fail to differentiate. Multimodal treatment approach has improved the outcome of RMS during the recent years. However, in case of relapsed or metastatic disease, the prognosis is still very poor. This indicates a high demand for novel targeted therapy approach for RMS. Prox1 transcription factor has been shown to regulate myoblast differentiation into skeletal muscle fibers. ... 
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KW  - Rhabdomyosarcoma; Prox1; high—throughput drug screening; proteasome; HDAC; inhibitor; Cancer; Cancer; Cancer; Translationaalisen lääketieteen maisteriohjelma; Master's Programme in Translational Medicine; Magisterprogrammet i translationell medicin 
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ER  -