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T1  - The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153 
SN  -  /  
UR  - http://hdl.handle.net/10138/209962 
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A1  - Siyo, Vuyolwethu; Schaefer, Georgia; Hunter, Roger; Grafov, Andriy; Grafova, Iryna; Nieger, Martin; Katz, Arieh A.; Parker, M. Iqbal; Kaschula, Catherine H. 
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Y1  - 2017 
LA  - eng 
AB  - Garlic is a food and medicinal plant that has been used in folk medicine since ancient times for its beneficial health effects, which include protection against cancer. Crushed garlic cloves contain an array of small sulfur-rich compounds such as ajoene. Ajoene is able to interfere with biological processes and is cytotoxic to cancer cells in the low micromolar range. BisPMB is a synthetic ajoene analogue that has been shown in our laboratory to have superior cytotoxicity to ajoene. In the curre... 
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KW  - ajoene; garlic; cancer prevention; ER stress; unfolded protein response; CHOP/GADD153; ENDOPLASMIC-RETICULUM STRESS; HUMAN PROMYELOLEUKEMIC CELLS; DISULFIDE INDUCES APOPTOSIS; UNFOLDED PROTEIN RESPONSE; DIALLYL DISULFIDE; TUMOR-CELLS; ORGANOSULFUR COMPOUNDS; MITOCHONDRIAL PATHWAY; CARCINOMA-CELLS; ER-STRESS; 116 Chemical sciences 
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