TY - T1 - The Immunogenetic Conundrum of Preeclampsia SN - / UR - http://hdl.handle.net/10138/278420 T3 - A1 - Lokki, A. Inkeri; Heikkinen-Eloranta, Jenni K.; Laivuori, Hannele A2 - PB - Y1 - 2018 LA - eng AB - Pregnancy is an immunological challenge to the mother. The fetal tissues including the placenta must be protected from activation of the maternal immune system. On the other hand, the placental tissue sheds into the maternal circulation and must be adequately identified and phagocytized by the maternal immune system. During a healthy pregnancy, numerous immunosuppressive processes take place that allow the allograft fetus to thrive under exposure to humoral and cellular components of the materna... VO - IS - SP - OP - KW - preeclampsia; genetics; complement; major histocompatibility complex; FLT1; autoimmunity; pregnancy; HEMOLYTIC-UREMIC SYNDROME; COFACTOR PROTEIN CD46; SYSTEMIC-LUPUS-ERYTHEMATOSUS; COMPLEMENT ACTIVATION; ANGIOGENIC FACTORS; EARLY GESTATION; MATERNAL KIR; HLA-G; PREGNANCY; CELLS; 3123 Gynaecology and paediatrics; 3111 Biomedicine N1 - PP - ER -