TY  -  
T1  - The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance 
SN  -  /  
UR  - http://hdl.handle.net/10138/325758 
T3  -  
A1  - Vannini, Nicola; Campos, Vasco; Girotra, Mukul; Trachsel, Vincent; Rojas-Sutterlin, Shanti; Tratwal, Josefine; Ragusa, Simone; Stefanidis, Evangelos; Ryu, Dongryeol; Rainer, Pernille Y.; Nikitin, Gena; Giger, Sonja; Li, Terytty Y.; Semilietof, Aikaterini; Oggier, Aurelien; Yersin, Yannick; Tauzin, Loic; Pirinen, Eija; Cheng, Wan-Chen; Ratajczak, Joanna; Canto, Carles; Ehrbar, Martin; Sizzano, Federico; Petrova, Tatiana V.; Vanhecke, Dominique; Zhang, Lianjun; Romero, Pedro; Nahimana, Aimable; Cherix, Stephane; Duchosal, Michel A.; Ho, Ping-Chih; Deplancke, Bart; Coukos, George; Auwerx, Johan; Lutolf, Matthias P.; Naveiras, Olaia 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD(+)-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a signif... 
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KW  - STEM-CELL TRANSPLANTATION; GREEN FLUORESCENT PROTEIN; SELF-RENEWAL; LIFE-SPAN; METABOLIC CHECKPOINT; PROGENITOR CELLS; MITOPHAGY; AUTOPHAGY; HOMEOSTASIS; LONGEVITY; 1182 Biochemistry, cell and molecular biology 
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ER  -