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T1  - The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue 
SN  -  /  
UR  - http://hdl.handle.net/10138/333732 
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A1  - Qadri, Sami; Lallukka-Brück, Susanna; Luukkonen, Panu K.; Zhou, You; Gastaldelli, Amalia; Orho-Melander, Marju; Sammalkorpi, Henna; Juuti, Anne; Penttilä, Anne K.; Perttilä, Julia; Hakkarainen, Antti; Lehtimäki, Tiina E.; Oresic, Matej; Hyötyläinen , Tuulia; Hodson, Leanne; Olkkonen, Vesa M.; Yki-Järvinen, Hannele 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Background & Aims The I148M variant in PNPLA3 is the major genetic risk factor for non-alcoholic fatty liver disease (NAFLD). The liver is enriched with polyunsaturated triglycerides (PUFA-TGs) in PNPLA3-I148M carriers. Gene expression data indicate that PNPLA3 is liver-specific in humans, but whether it functions in adipose tissue (AT) is unknown. We investigated whether PNPLA3-I148M modifies AT metabolism in human NAFLD. Methods Profiling of the AT lipidome and fasting serum non-esterified fat... 
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KW  - adipose tissue; fatty acids; lipidomics; lipolysis; non-alcoholic fatty liver disease; triglycerides; FATTY LIVER-DISEASE; DOMAIN-CONTAINING 3; GENETIC-VARIATION; INSULIN-RESISTANCE; ACIDS; ADIPONUTRIN; OBESITY; STEATOSIS; GLUCOSE; SUSCEPTIBILITY; 3121 General medicine, internal medicine and other clinical medicine 
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