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T1  - The Phenotype of Celiac Disease Has Low Concordance between Siblings, Despite a Similar Distribution of HLA Haplotypes 
SN  -  /  
UR  - http://hdl.handle.net/10138/300740 
T3  -  
A1  - Kauma, Saana; Kaukinen, Katri; Huhtala, Heini; Kivelä, Laura; Pekki, Henna; Salmi, Teea; Saavalainen, Päivi; Lindfors, Katri; Kurppa, Kalle 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - The factors determining the presentation of celiac disease are unclear. We investigated the phenotypic concordance and the distribution of human leukocyte antigen (HLA) risk haplotypes in affected siblings. One hundred sibling pairs were included. Clinical and histological parameters and HLA haplotypes were compared between the first diagnosed indexes and their siblings. The phenotype was categorized into gastrointestinal, extra-intestinal, malabsorption/anemia, and asymptomatic. The phenotype w... 
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OP  -  
KW  - celiac disease; sibling; phenotype; gluten-free diet; environmental factors; genotype; DERMATITIS-HERPETIFORMIS; MICROBIOTA COMPOSITION; GENETIC DISSECTION; LONG-TERM; FOLLOW-UP; RISK; PREVALENCE; RELATIVES; 3143 Nutrition 
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ER  -