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T1  - The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients 
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UR  - http://hdl.handle.net/10138/225320 
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A1  - Fagerholm, Rainer; Schmidt, Marjanka K.; Khan, Sofia; Rafiq, Sajjad; Tapper, William; Aittomaki, Kristiina; Greco, Dario; Heikkinen, Tuomas; Muranen, Taru A.; Fasching, Peter A.; Janni, Wolfgang; Weinshilboum, Richard; Loehberg, Christian R.; Hopper, John L.; Southey, Melissa C.; Keeman, Renske; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Chenevix-Trench, Georgia; Lambrechts, Diether; Wildiers, Hans; Chang-Claude, Jenny; Seibold, Petra; Couch, Fergus J.; Olson, Janet E.; Andrulis, Irene L.; Knight, Julia A.; Garcia-Closas, Montserrat; Figueroa, Jonine; Hooning, Maartje J.; Jager, Agnes; Shah, Mitul; Perkins, Barbara J.; Luben, Robert; Hamann, Ute; Kabisch, Maria; Czene, Kamila; Hall, Per; Easton, Douglas F.; Pharoah, Paul D. P.; Liu, Jianjun; Eccles, Diana; Blomqvist, Carl; Nevanlinna, Heli; kConFab Investigators 
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Y1  - 2015 
LA  - eng 
AB  - We have utilized a two-stage study design to search for SNPs associated with the survival of breast cancer patients treated with adjuvant chemotherapy. Our initial GWS data set consisted of 805 Finnish breast cancer cases (360 treated with adjuvant chemotherapy). The top 39 SNPs from this stage were analyzed in three independent data sets: iCOGS (n=6720 chemotherapy-treated cases), SUCCESS-A (n=3596), and POSH (n=518). Two SNPs were successfully validated: rs6500843 (any chemotherapy; per-allele... 
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KW  - breast cancer; survival; SNP; chemotherapy; cell cycle; ESTROGEN-RECEPTOR-ALPHA; LARGE GENE LISTS; BRCA2 MUTATIONS; LUNG-CANCER; CELL-LINES; EXPRESSION; PROGNOSIS; OUTCOMES; REVEALS; SUSCEPTIBILITY; 3122 Cancers; 3123 Gynaecology and paediatrics 
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