TY  -  
T1  - The Swinholide Biosynthesis Gene Cluster from a Terrestrial Cyanobacterium, Nostoc sp. Strain UHCC 0450 
SN  -  /  
UR  - http://hdl.handle.net/10138/233639 
T3  -  
A1  - Humisto, Anu Karoliina; Jokela, Jouni Kalevi; Liu, Liwei; Wahlsten, Matti Per-Vilhelm; Wang, Hao; Permi, Perttu Esko Ilari; Machado, João Paulo; Antunes, Agostinho; Fewer, David Peter; Sivonen, Anna Kaarina 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Swinholides are 42-carbon ring polyketides with a 2-fold axis of symmetry. They are potent cytotoxins that disrupt the actin cytoskeleton. Swinholides were discovered from the marine sponge Theonella sp. and were long suspected to be produced by symbiotic bacteria. Misakinolide, a structural variant of swinholide, was recently demonstrated to be the product of a symbiotic heterotrophic proteobacterium. Here, we report the production of swinholide A by an axenic strain of the terrestrial cyanobac... 
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IS  -  
SP  -  
OP  -  
KW  - 1183 Plant biology, microbiology, virology; cyanobacteria; Nostoc; "Candidatus Entotheonella"; polyketides; trans-AT PKS; swinholide; scytophycin; horizontal gene transfer; Anabaena; SPONGE THEONELLA-SWINHOEI; CYTOTOXIC DIMERIC MACROLIDES; NATURAL-PRODUCT DISCOVERY; NONRIBOSOMAL PEPTIDE; POLYKETIDE SYNTHASES; MARINE CYANOBACTERIA; DIVERSITY; EVOLUTION; CONGENERS; INSIGHTS 
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ER  -