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T1  - The angiotensin receptor 2 agonist, compound 21, facilitates TRKB activation and reduces the consequences of stress in mice 
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UR  - URN:NBN:fi:hulib-202106243235; http://hdl.handle.net/10138/331829 
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A1  - Laukkanen, Liina 
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PB  - Helsingin yliopisto 
Y1  - 2021 
LA  - eng 
AB  - This study investigated the in vitro and in vivo effects of direct angiotensin II (ANG) receptor type 2 (AGTR2) agonist Compound 21 (C21). The blockade of ANG receptor type 1 (AGTR1) by AGTR1 antagonists has long been associated with antidepressant and anxiolytic effects. Furthermore, it has been suggested that the therapeutic effects of the AGTR1 antagonists are partially dependent on enhancing the signaling through neuroprotective AGTR2. This suggests that as a specific AGTR2 agonist C21 could... 
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KW  - Compound 21 (C21); angiotensin receptor type 2 (AGTR2); angiotensin receptor agonist; stress; brain-derived neurotrophic factor (BDNF); tropomyosin receptor kinase B (TRKB); Compound 21 (C21); angiotensin receptor type 2 (AGTR2); angiotensin receptor agonist; stress; brain-derived neurotrophic factor (BDNF); tropomyosin receptor kinase B (TRKB); Neuroscience and psychobiology; Neuroscience and psychobiology; Neuroscience and psychobiology; Translationaalisen lääketieteen maisteriohjelma (Translational Medicine); Master's Programme in Translational Medicine; Magisterprogrammet i translationell medicin 
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