TY - T1 - The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor SN - / UR - http://hdl.handle.net/10138/335440 T3 - A1 - Eesmaa, Ave; Yu, Li-Ying; Göös, Helka; Nõges, Kristofer; Kovaleva, Vera; Hellman, Maarit; Zimmermann, Richard; Jung, Martin; Permi, Perttu; Varjosalo, Markku; Lindholm, Paivi; Saarma, Mart A2 - PB - Y1 - 2021 LA - eng AB - Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of... VO - IS - SP - OP - KW - ENDOPLASMIC-RETICULUM STRESS; NEUROTROPHIC FACTOR MANF; ER-STRESS; COMPREHENSIVE RESOURCE; BIP; BINDING; ATF6; ATP; DISSOCIATION; IRE1-ALPHA; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -