TY - T1 - The effect of light sensitizer localization on the stability of indocyanine green liposomes SN - / UR - http://hdl.handle.net/10138/239088 T3 - A1 - Lajunen, Tatu; Nurmi, Riikka; Wilbie, Danny; Ruoslahti, Teemu; Johansson, Niklas G.; Korhonen, Ossi; Rog, Tomasz; Bunker, Alex; Ruponen, Marika; Urtti, Arto A2 - PB - Y1 - 2018 LA - eng AB - Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy, providing both temporal and spatial control of drug release. We have developed light triggered liposomes with clinically approved indocyanine green (ICG) as the light sensitizing compound. Amphiphilic ICG can be localized in different compartments of the liposomes, but the effect of its presence, on both triggered release and long term stability, has not been studied. In this work, we report that ICG ... VO - IS - SP - OP - KW - Liposome; Indocyanine green; Polyethylene glycol; Drug delivery system; Triggered release; Stability; DRUG-DELIVERY SYSTEMS; POLYETHYLENE-GLYCOL DERIVATIVES; MOLECULAR-DYNAMICS SIMULATION; RETINAL-PIGMENT EPITHELIUM; ATOM FORCE-FIELD; IN-VIVO; PHOTOINITIATED DESTABILIZATION; PHOTOSENSITIVE LIPOSOMES; FLUORESCENCE PROPERTIES; GOLD NANOPARTICLES; 116 Chemical sciences; 317 Pharmacy N1 - PP - ER -