TY  -  
T1  - The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy 
SN  -  /  
UR  - http://hdl.handle.net/10138/319279 
T3  -  
A1  - Kilpeläinen, Tommi P.; Hellinen, Laura; Vrijdag, Johannes; Yan, Xu; Svarcbahs, Reinis; Vellonen, Kati-Sisko; Lambeir, Anne-Marie; Huttunen, Henri; Urtti, Arto; Wallen, Erik A. A.; Myohanen, Timo T. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (alpha Syn), linking it to the pathophysiology of Parkinson's disease. Our earlier results have revealed that the potent small molecular PREP inhibitor KYP-2047 is able to increase autophagy and decrease dimerization of alpha Syn but other PREP inhibitors have not been systematically studied for these two protein-protein interaction mediated biological fun... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Serine protease; Alpha-Synuclein; Autophagy; Parkinson's disease; Protein conformation; ACTIVE-SITE; CELL; KYP-2047; PROTEIN; BRAIN; ENDOPEPTIDASE; PROLINE; 317 Pharmacy 
N1  -   
PP  -  
ER  -